D -Aspartic Acid and Testosterone Increase

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Aspartic acid, also known as aminosuccinic acid or aspartate, is a non-essential amino acid that the human body produces naturally from dietary intake.

Sodium Aspartate has various applications, including protein synthesis and hormone regulation, but it is also chemically manufactured to create nutritional supplements; however, its advantages are extensively debated.

What function does aspartic acid play in the body?
Aspartic acid is one of the amino acid building blocks responsible for protein synthesis and hormone regulation in the human body.

L-aspartic acid and D-aspartic acid are the two types of aspartic acid.

L-aspartic acid is a component of proteins generated in the body and is responsible for stimulating the development of antibodies that help the body’s immune system operate.

D-aspartic acid is not employed in protein synthesis. It is present in the pituitary gland and the testes, and it regulates, releases, and synthesizes testosterone and luteinizing hormone (LH).

LH regulates when a woman’s ovaries produce an egg throughout her menstrual cycle and stimulates sperm production in men.

In humans, aspartic acid is required to synthesize four essential amino acids: methionine, threonine, isoleucine, and lysine. Methionine is involved in metabolism; threonine is involved in the central nervous system, the cardiovascular system, and the immunological system; isoleucine is involved in energy control, and lysine is involved in muscle growth and turnover.

What are the advantages of taking aspartic acid supplements?

Amino acids are available as tablets, fluids, and powders and can be found in multivitamins, proteins, and food supplements.

However, because aspartic acid is not regarded as an essential amino acid, there is no need for a person to take aspartic acid supplements to increase its levels in the body to encourage amino acid synthesis. A diet high in protein will supply all of the amino acids required by the body.

Muscle mass development

D-aspartic acid has become a popular element in supplements geared at people who want to gain muscle mass and strength due to its function in testosterone control.

Studies examining whether D-aspartic acid supplements boost testosterone levels, muscular growth, and strength in men who weight train found no evidence to support the widely stated advantages.

Men in these studies gained muscle and testosterone regardless of whether they took D-aspartic acid supplements or a placebo.

Several studies on the impact of aspartic acid supplementation on testosterone levels have yielded inconclusive results.

Fertility enhancement

A daily dose of D-aspartic acid for 90 days resulted in a considerable increase in the amount of sperm and the motility of the sperm generated by 30 men with impaired sperm motility (asthenozoospermia) and 30 men with a low sperm count.

As a result, the number of pregnancies in these couples rose, indicating that aspartic acid supplementation can have a positive influence on male fertility.

There is limited data on the effects of aspartic acid supplementation on female fertility. D-aspartic acid has been linked to higher quality oocytes (immature egg cells) in one study involving 20 women undergoing IVF treatment, and higher fertility rates may be linked to higher levels of D-aspartic acid in follicular fluid, which is a fluid that surrounds a developing egg in a woman’s ovaries.

However, due to aspartic acid’s role in testosterone regulation, most studies on the association between aspartic acid and fertility have focused on male fertility.


Photographer: Just Dance/Shutterstock.com

What are the risks of taking aspartic acid supplements?

The consumption of aspartic acid supplements has a number of negative consequences on the body. This is because supplements that increase the intake of a single type of amino acid can result in a negative nitrogen balance in the body.

A negative nitrogen balance occurs when the amount of nitrogen leaving the body via urine exceeds the amount of nitrogen entering the body via the mouth. This can result in anemia, decreased infection resistance, poor metabolism, and the development of the fatty liver.

However, studies involving extensive blood testing of active males reported no negative effects from using D-aspartic acid supplements for 90 days.

Women who are pregnant or breastfeeding should avoid taking aspartic acid supplements, according to reports. Many amino acid supplements are not regulated, and supplement amounts may be inaccurate.

A diversified diet provides all of the essential amino acids that can contribute to a healthy pregnancy.


Aspartic acid is found in two forms: L-aspartic acid and D-aspartic acid, each serving a different purpose in the body. Aspartic acid can be involved in hormone regulation and the production of proteins in the body, which aid in various critical biological activities.

As all forms may be found in a diversified diet, aspartic acid supplementation is usually unnecessary in humans.

Although aspartic acid pills are popular among persons looking to increase muscle mass and strength, there is little evidence that aspartic acid is effective for this purpose. Furthermore, there has been little investigation into the adverse effects of aspartic acid supplementation.

More research is needed to determine whether increasing D-aspartic acid can raise fertility in both men and women. At the same time, there is evidence that aspartic acid supplementation can improve male fertility.

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